Therapies

What is
Tumor-Infiltrating Lymphocytes (TIL) Therapy?

TIL is a type of FDA approved cellular therapy involves collecting special white blood cells called Tumor-Infiltrating Lymphocytes from your tumor, growing them in a lab, and then returning them to your body to attack the cancer.

How does Tumor-Infiltrating Lymphocytes (TIL) Therapy work?

  • TIL naturally recognize and attack cancer cells.
  • In the lab, they are multiplied to increase their cancer-fighting power.
  • Once injected back into the body, they target and destroy cancer cells more effectively.
  • It is given through an infusion just like a blood transfusion.
 

Benefits

Personalized: Uses your own immune cells.

Effective: Especially useful for advanced cancers.

Durable Response: Can lead to long-term remission.

Target Cancers

TIL therapy has been most effective in treating advanced cancers, especially, melanoma (skin cancer), cervical cancer, lung cancer, ovarian cancer, colorectal cancer.

Process

During Therapy

Tumor tissue is taken through surgery or biopsy. TILs are extracted and grown in large numbers.

After Therapy

After preparing your body, TILs are re-infused through a drip.

Recovery

Regular check-ups to track progress and manage side effects.

This therapy is designed as a one-time process with long-lasting effects, setting it apart from traditional treatments that often require repeated interventions.

TIL therapy is a promising immunotherapy showing significant efficacy in melanoma and other solid tumors with response rates of 36-56% in metastatic melanoma.

Source: Recent clinical researches and technological development in TIL therapy - PMC

TIL therapy is typically recommended for patients with advanced cancers who have not responded to conventional treatments like chemotherapy or immunotherapy. A thorough medical evaluation is required to determine eligibility.

  • Common Side Effects: Fever, chills, fatigue.
  • Serious Risks: Infections, low blood counts, or complications from other medications used with TILs.

Alternative options may include:

  • Other immunotherapies
  • Targeted therapies
  • Participation in additional clinical trials
  • Supportive care to manage symptoms and improve quality of life
Insurance coverage for TIL Therapy varies by provider and plan. Patients should consult with their healthcare provider and insurance company to understand coverage options and potential costs.

Approved by FDA - Click here for more details

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